Mediterranean Journal of Hematology and Infectious Diseases

Neonatal sepsis is a major cause of morbidities and mortalities mostly remarkable in the third world nations.We aimed to assess the value of simultaneous measurement of procalcitonin (PCT) and interleukin-6 (IL-6) in association with high sensitive prediction of early neonatal sepsis. A follow-up study was performed clinical signs of sepsis or maternal risk factors for sepsis. Neonates were assigned to 4 groups including “proven early-onset sepsis”, “clinical early “uncertain infectious status”. Blood samples were obtained within the first 12 h of b between 24 hours and 36 hours of age for determination of serum levels of PCT, IL white blood cell (WBC) count. On admission, neonates with sepsis had a higher WBC count, IL compared with those neonates without sepsis. This remained significant even after 12 admission. Also, patients with clinical evidences of sepsis had a higher serum level of PCT and IL within 12-24 hours after admission compared to the patients with uncertain sepsis. The combination of PCT and ILcutoff value of 8 mg/L) a sensitivity of 82%.The areas under the ROC curve for the two periods were 0.801 , and 0.819 respectively. In final The combination of IL-6, onset neonatal sepsis. Introduction. Neonatal sepsis is a major cause of morbidities and mortalities mostly remarkable in the third world nations. Early diagnosis and subsequent therapy for the infected infants or those with a higher www.mjhid.org ISSN 2035-3006 alcitonin, Interleukin -Onset Neonatal Sepsis